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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are usually characterized by a focus on the practical aspects of the study design, including the recruitment process and consent as well as adherence to the use of commonly available equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from various geographical areas. This kind of heterogeneity is required for pragmatic trials to be able to prove their validity and helps reduce bias in the results. However excessive heterogeneity could lead to problems with the design of the trial.
Pragmatic Play Pragmatic Play, one of the major players in the live casino market, provides various classic table games such as Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta offer customers an authentic experience in gambling as well a full variety of betting options via virtual. The company also hosts a variety of game shows which make online gambling fun and interactive. Some of these shows feature live hosts, whereas others are hosted by prominent personalities from the industry.
Mobile compatibility
Pragmatic Play is a relatively new player in the online casino market, but it has made a name for itself with its mobile-friendly slots. Their games are optimised for mobile devices and are powered by HTML5 technology. They are also licensed and regulated by trusted gaming authorities, which ensure fairness and transparency. This is a positive sign for players as it indicates that the games have been tested and validated to ensure randomness and fairness of every round.
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Legality
Pragmatic Play is known for its top-quality games and for providing a superior user experience. Its software is designed to work with mobile devices and supports different languages. Despite its infancy it has already established itself as a leading gaming platform for casinos. Wolves is one of its latest releases that is a 5-reel slot machine with a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.
The aim of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. They are usually commissioned by policymakers and practitioners to inform their decisions. They are also a good method of determining the cause-effect relationship between an intervention and its results. They should not, however be used to replace explanation studies.
The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a practical trial which includes the recruitment process, the design and implementation of the intervention, as well as monitoring.
There is a growing increase in the number pragmatic trials that have been published. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind, however, that the majority of studies were conducted in primary care settings.